Results
| PMID | 27328518 |
| Gene Name | NECTIN4 |
| Condition | Endometriosis |
| Association |
Associated |
| Population size | 80 |
| Population details | 80 (20 women with ovarian endometriosis, 20 women with peritoneal endometriosis, 20 women with endometrium of endometriosis, 20 women in a control group (having no endometriosis)) |
| Sex | Female |
| Other associated phenotypes |
Endometriosis |
|
Clin Exp Obstet Gynecol. 2016;43(3):463-6. Bedir, R| Sehitoglu, I| Balik, G| Kagitci, M| Gucer, H| Yurdakul, C| Bagci, P OBJECTIVE: Nectins are immunoglobulin-like adhesion molecules, and they play important role in cell proliferation and tumor metastasis. The objective in this study was to compare the expression of Nectin-4 in normal endometrium and in ectopic endometriotic tissues. MATERIALS AND METHODS: Nectin-4 expression was investigated in ovarian endometriosis (n = 20), peritoneal endometriosis (n = 20), endometrium of endometriosis (n = 20), and in a control group (having no endometriosis) (n = 20) by immunohistochemical method. RESULTS: Nectin-4 expression, when compared with control group, was higher in endometriotic lesions of patients having ovarian endometriosis and peritoneal endometriosis (p = 0.003 and p = 0.009, respectively). This difference was significant in the endometrium of patients having endometriosis (p = 0.011). CONCLUSION: The authors believe that Nectin-4 molecule may contribute to the pathogenesis of endometriosis. For this reason, the use of medicines developed against this molecule in the treatment of endometriosis may be useful. Mesh Terms: Adult| Case-Control Studies| Cell Adhesion Molecules/*metabolism| Endometriosis/*metabolism| Endometrium/*metabolism| Female| Humans| Immunohistochemistry| Middle Aged| Ovarian Diseases/*metabolism| Peritoneal Diseases/*metabolism|DA 2016/07/29 |
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